Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging.

  title={Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging.},
  author={Tian Jin and Heng Guo and Huabei Jiang and Bowen Ke and Lei Xi},
  journal={Optics letters},
  volume={42 21},
Optical resolution photoacoustic microscopy (ORPAM) represents one of the fastest evolving optical microscopic techniques. However, due to the bulky size and complicated system configuration of conventional ORPAM, it is largely limited to small animal experiments. In this Letter, we present the design and evaluation of a portable ORPAM with a high spatiotemporal resolution and a large field of view. In this system, we utilize a rotatory scanning mechanism instead of the conventional raster… 
Optical resolution photoacoustic computed microscopy.
This study proposes and evaluates a new ORPAM modality termed as optical resolution photoacoustic computed microscopy (ORPACM), through the combination of a two-dimensional laser-scanning system with a medical ultrasonographic platform, which reveals more detailed information compared with conventional single-element transducer-based ORPAMS.
High-speed dual-view photoacoustic imaging pen.
The experimental results prove that the PAI pen can clearly image the microvessels of the oral cavity, which indicates that it has the same imaging capability for other similar areas and has a good prospect for assisting the diagnosis of related diseases.
A handheld microscope integrating photoacoustic microscopy and optical coherence tomography.
The design and evaluation of an integrated ORPAM and OCT imaging probe using a two-dimensional MEMS (micro-electro-mechanical-system)-based optical scanner is reported, carrying out oral imaging of a healthy volunteer to show the clinical feasibility of this technique.
In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography
Oral diseases, especially oral cancers, are becoming serious health problems in humans. To image vasculatures and structures simultaneously in the human oral cavity which are tightly associated with
Ultrafast optical resolution photoacoustic microscopy in vivo
Photoacoustic Imaging (PAI) is an emerging non-ionizing and non-invasive biomedical imaging method in the past few years. PAI can effectively obtain both structural and functional information of
Waterproof Galvanometer Scanner-Based Handheld Photoacoustic Microscopy Probe for Wide-Field Vasculature Imaging In Vivo
Photoacoustic imaging (PAI) is a hybrid non-invasive imaging technique used to merge high optical contrast and high acoustic resolution in deep tissue. PAI has been extensively developed by utilizing
Recent advances toward clinical applications of photoacoustic microscopy: a review
The principles of PAM are reviewed and its applications to human tissues, including the breast tissue, carotid atheroma tissue, eye, gastrointestinal tissue, ovarian tissue and tooth ex vivo as well as the oral cavity and dermatological tissue in vivo are reviewed.
Large-field-of-view optical resolution photoacoustic microscopy.
A large-field-of-view ORPAM (L-ORPAM) is reported using a combination of a new scanning mechanism and an ultrafast pulsed laser that has sufficient contrast, resolution and spatial FOV to carry out studies of large rodents.


Multiscale photoacoustic microscopy and computed tomography.
PAT holds the promise of in vivo imaging at multiple length scales ranging from subcellular organelles to organs with the same contrast origin, an important application in multiscale systems biology research.
Biomedical photoacoustic imaging
The underlying physical principles of the technique, its practical implementation, and a range of clinical and preclinical applications are reviewed.
Combined photoacoustic and ultrasound biomicroscopy.
We report on the development of an imaging system capable of combined ultrasound and photoacoustic imaging based on a fast-scanning single-element 25-MHz ultrasound transducer and a unique
Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques.
A multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI) is reported, allowing for enhanced in vivo detection of oral carcinoma.
Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection.
The combined PAT/DOT system takes full advantages of two different modalities to provide complementary information and most accurate recovery of tissue optical properties and will allow the hybrid system to test in humans with breast cancer in the near future.
Optoacoustic imaging of oral cancer: feasibility studies in hamster model of squamous cell carcinoma
An otoacoustic transducer capable of detecting wide-band ultrasonic profiles at the site of pulsed laser irradiation was developed and applied in imaging various stages of squamous cell carcinoma
Variable-thickness multilayered polyvinylidene fluoride transducer with improved sensitivity and bandwidth for photoacoustic imaging
The performance of photoacoustic imaging (PAI) is critically dependent on the sensitivity and bandwidth of the transducer. Here, we report the design and fabrication of a polyvinylidene fluoride
Narrow band imaging: a new diagnostic approach to visualize angiogenesis in superficial neoplasia.
  • M. Muto, C. Katada, Y. Sano, S. Yoshida
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2005
Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence.
Consistent differences exist between the fluorescence spectra of abnormal and normal oral mucosa, and fluorescence Spectroscopy has the potential to improve the noninvasive diagnosis of oral cavity neoplasia.