Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases.

@article{Linne2001PortabilityOE,
  title={Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases.},
  author={Uwe Linne and Sascha Doekel and Mohamed A. Marahiel},
  journal={Biochemistry},
  year={2001},
  volume={40 51},
  pages={15824-34}
}
Incorporation of nonproteinogenic amino acids in small polypeptides synthesized by nonribosomal peptide synthetases (NRPS) significantly contributes to their biological activity. In these peptides, conversion of L-amino acids to the corresponding D-isomer is catalyzed by specialized NRPS modules that utilize an epimerization (E) domain. To understand the basis for the specific interaction of E domains with PCP domains (peptidyl carrier proteins, also described as T domains) and to investigate… CONTINUE READING

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