Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis.

  title={Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis.},
  author={Niki M Moutsopoulos and Heather M Kling and Nikola Angelov and Wenwen Jin and Robert J. Palmer and Salvador Nares and Manuel Osorio and Sharon M. Wahl},
  journal={Journal of autoimmunity},
  volume={39 4},
In periodontitis, a common chronic inflammatory condition, gram-negative-rich bacterial biofilms trigger, in susceptible individuals, perpetuating inflammation that results in extensive tissue damage of tooth supporting structures. To delineate immune cell-dependent mechanisms whereby bacterial challenge drives persistent destructive inflammation in periodontitis and other inflammatory diseases, we studied involved tissues ex vivo and investigated host cell responses to the periodontal pathogen… CONTINUE READING


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