Porphyromonas gingivalis lipopolysaccharide inhibits the osteoblastic differentiation of preosteoblasts by activating Notch1 signaling.

@article{Xing2010PorphyromonasGL,
  title={Porphyromonas gingivalis lipopolysaccharide inhibits the osteoblastic differentiation of preosteoblasts by activating Notch1 signaling.},
  author={Quan Xing and Qingsong Ye and Ming-Wen Fan and Yi Zhou and Qiang Xu and Andrew Sandham},
  journal={Journal of cellular physiology},
  year={2010},
  volume={225 1},
  pages={106-14}
}
Although Porphyromonas gingivalis lipopolysaccharide (P-LPS) is known to inhibit osteoblast differentiation, the exact molecular mechanisms underlying this phenomenon remain unclear. Here, we investigated the role of Notch signaling in the osteoblastic differentiation of both MC3T3E-1 cells and primary mouse bone marrow stromal cells (BMSCs). P-LPS stimulation activated the Notch1 signaling cascade and increased expression of the Notch target genes HES1 and HEY1. P-LPS can also act as an… CONTINUE READING

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