Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1/Th2 cytokine ratio, and fetal growth restriction.

@article{Lin2003PorphyromonasGI,
  title={Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1/Th2 cytokine ratio, and fetal growth restriction.},
  author={Dongming Lin and Mary Alice Smith and John R Elter and Catherine M Champagne and Christine Lynn Downey and James D. Beck and Steven Offenbacher},
  journal={Infection and immunity},
  year={2003},
  volume={71 9},
  pages={5163-8}
}
Our previous animal studies showed that maternal Porphyromonas gingivalis infection in a subcutaneous chamber is associated with hepatic and uterine translocation, as well as systemic induction of maternal inflammatory responses, both of which were associated with fetal growth restriction (FGR). However, P. gingivalis-challenged dams had fetuses with either FGR (2 standard deviations below mean weight of nonchallenged dams) or normal weight. Therefore, the objective of this study was to… CONTINUE READING

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