Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4.

@article{Lin2014PorphyromonasGE,
  title={Porphyromonas gingivalis exacerbates ligature-induced, RANKL-dependent alveolar bone resorption via differential regulation of Toll-like receptor 2 (TLR2) and TLR4.},
  author={Jiang Lin and Liangjia Bi and Xiaoqian Yu and Toshihisa Kawai and Martin A. Taubman and Baozhong Shen and Xiaozhe Han},
  journal={Infection and immunity},
  year={2014},
  volume={82 10},
  pages={4127-34}
}
Toll-like receptors (TLRs) play a key role in the innate immune responses to periodontal pathogens in periodontal disease. The present study was performed to determine the roles of TLR2 and TLR4 signaling in alveolar bone resorption, using a Porphyromonas gingivalis-associated ligature-induced periodontitis model in mice. Wild-type (WT), Tlr2(-/-), and Tlr4(-/-) mice (8 to 10 weeks old) in the C57/BL6 background were used. Silk ligatures were applied to the maxillary second molars in the… CONTINUE READING
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