Porphyrinogenicity of etomidate and ketamine as continuous infusions. Screening in the DDC-primed rat model.

Abstract

The porphyrinogenicity of etomidate and ketamine administered as continuous i.v. infusions was screened in the DDC-primed rat model of latent variegate porphyria. Ketamine produced no change from control in 5-aminolaevulinate synthase (ALAs) activity and haem intermediate production in either untreated or DDC-primed rats, and would appear to be safe for use… (More)

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