Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells.

@article{Pereira2014PorphyrinCW,
  title={Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells.},
  author={Patr{\'i}cia M Pereira and Jose Joao De Carvalho and Simone Ribeiro e Silva and Jos{\'e} A S Cavaleiro and Rudolf J Schneider and Rosa Maria Valente Fernandes and Jo{\~a}o P C Tom{\'e}},
  journal={Organic & biomolecular chemistry},
  year={2014},
  volume={12 11},
  pages={
          1804-11
        }
}
The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti… CONTINUE READING
1
Twitter Mention

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS