Porphyrin Abiogenesis from Pyrrole and Formaldehyde under Simulated Geochemical Conditions

@article{Hodgson1967PorphyrinAF,
  title={Porphyrin Abiogenesis from Pyrrole and Formaldehyde under Simulated Geochemical Conditions},
  author={Gordon W. Hodgson and Bruce L. Baker},
  journal={Nature},
  year={1967},
  volume={216},
  pages={29-32}
}
Experiments with gas mixtures intended to simulate primeval atmospheres have yielded a great many types of chemicals of biological interest. It has now been shown that metal porphyrin complexes are commonly produced in these experiments. 
[Abiogenic formation of porphin, chlorine and bacterioclorine].
Oparin’s hypothesis (1) maintaining that a prolonged chemical evolution preceded the emergence of life on Earth gave impetus to numerous investigations whose purpose was to reveal probable pathwaysExpand
Porphyrin-like compounds genesis under simulated abiotic conditions
TLDR
Investigations into the synthesis of porphyrinlike compounds from methane, ammonia and water vapour by using high frequency discharges showed the ready formation of these compounds in abiotic conditions, suggesting the possibility of their appearance during the early stage of chemical evolution. Expand
Prebiotic porphyrin genesis: porphyrins from electric discharge in methane, ammonia, and water vapor.
  • G. Hodgson, C. Ponnamperuma
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1968
TLDR
Prebiotic genesis of porphyrin synthesized under electric discharge conditions in methane ammonia water systems under methane ammonia drinking water systems is studied. Expand
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It is questionable whether magnesium porphyrins, i.e. possible ancestors of chlorophyll, could have accumulated in primordial rock pools, however, abiotically formed ancestors of the modern cofactors heme (Fe), B12 (Co), and F430 (Ni) may have been available to hypothetical protometabolisms and early organisms. Expand
Porphyrin Synthesis Using Clays. Taking Advantage of Statistical Product Distributions
Solid acids such as the K10 montmorillonite are useful for preparation of porphyrins from pyrrole condensed with aldehydes. Combining the use of two different aldehydes A and B with unequal,Expand
Clay-mediated meso-tetraarylporphyrin synthesis
Abstract meso -Tetraalporphyrin syntheses from aromatic aldehydes and pyrrole in clay nanospaces were investigated. The clay-promoted porphyrin synthesis was also contrasted with the Lindsey BF 3Expand
Porphinogen Formation from the Co-Oligomerization of Formaldehyde and Pyrrole: Free Energy Pathways.
TLDR
The nonoxidative stepwise co-oligomerization of formaldehyde and pyrrole to form porphinogen is investigated using density functional theory calculations that include free energy corrections, finding that this reaction is reversible in aqueous solution. Expand
Chemical evolution, recent syntheses of bioorganic molecules
This review covers important developments in abiological synthesis of biomonomers and biopolymers since about 1967. The significance of these experiments to the field of chemical evolution and theExpand
PHOTOCHEMISTRY OF PORPHYRINS: A MODEL FOR THE ORIGIN OF PHOTOSYNTHESIS *
TLDR
A series of porphyrins and catalysts have been used to test the hypotheses that the biosynthetic pathway to chlorophyll recapitulates the evolutionary history of photosynthesis and the proto‐photosynthetic function of biogenetic p Morphyrins was the oxidation of organic molecules by photoexcited porphyrs with the attendant emission of molecular hydrogen. Expand
Some Reflections on Prebiotic Porphyrins and Their Complexes with Other Primordial Compounds
TLDR
All forms of life require porphyrins for chlorophylls and/or hemes, in addition to amino and nucleic acids and proteins of various types, and the appropriate combination of certain of these might have provided simple photosynthetic or other systems essential for primeval life. Expand
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