Porphobilinogen deaminase and uroporphyrinogen III synthase: structure, molecular biology, and mechanism.

@article{ShoolinginJordan1995PorphobilinogenDA,
  title={Porphobilinogen deaminase and uroporphyrinogen III synthase: structure, molecular biology, and mechanism.},
  author={Peter M. Shoolingin-Jordan},
  journal={Journal of bioenergetics and biomembranes},
  year={1995},
  volume={27 2},
  pages={181-95}
}
Porphobilinogen deaminase (hydroxymethylbilane synthase) and uroporphyrinogen III synthase (uroporphyrinogen III cosynthase) catalyze the transformation of four molecules of porphobilinogen, via the 1-hydroxymethylbilane, preuroporphyrinogen, into uroporphyrinogen III. A combination of studies involving protein chemistry, molecular biology, site-directed mutagenesis, and the use of chemically synthesized substrate analogs and inhibitors is helping to unravel the complex mechanisms by which the… CONTINUE READING

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