Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo.

@article{Karageorgiou2006PorousSF,
  title={Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo.},
  author={Vassilis Karageorgiou and Michael Tomkins and Robert Fajardo and Lorenz Meinel and Brian S. Snyder and Katherine Wade and Jake Jinkun Chen and Gordana Vunjak-Novakovic and David L Kaplan},
  journal={Journal of biomedical materials research. Part A},
  year={2006},
  volume={78 2},
  pages={
          324-34
        }
}
Bone morphogenetic protein-2 (BMP-2) plays a key role in osteogenesis. Biomaterials used for the sustained delivery of BMP-2 in vivo have shown therapeutic benefits. In the present study, BMP-2 was loaded in porous silk fibroin scaffolds derived from silkworm cocoons (2.4 +/- 0.14 microg per scaffold). The release profile of BMP-2 under dynamic culture conditions (spinner flasks) showed that after 1 week in culture 25% of the initial BMP-2 was retained adsorbed to the scaffold; up to 4 weeks no… CONTINUE READING

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