• DOI:10.1038/nmat2608
• Corpus ID: 205403820

Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.

@article{Horcajada2010PorousMN,
  title={Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.},
  author={Patricia Horcajada and Tamim Chalati and Christian Serre and Brigitte Gillet and Catherine S{\'e}bri{\'e} and Tarek Baati and Jarrod F. Eubank and Daniela Heurtaux and Pascal Clayette and Christine Kreuz and Jong‐San Chang and Young Kyu Hwang and V{\'e}ronique Marsaud and Phuong Nhi Bories and Luc A. Cynober and Sophie Gil and G{\'e}rard F{\'e}rey and Patrick Couvreur and Ruxandra Gref},
  journal={Nature materials},
  year={2010},
  volume={9 2},
  pages={
          172-8
        }
}

• P. Horcajada, T. Chalati, +16 authors R. Gref
• Published 1 February 2010
• Biology, Materials Science
• Nature materials

In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments.