Porous bioprinted constructs in BMP-2 non-viral gene therapy for bone tissue engineering

@inproceedings{Loozen2013PorousBC,
  title={Porous bioprinted constructs in BMP-2 non-viral gene therapy for bone tissue engineering},
  author={Loek D Loozen and Fiona Wegman and Frank Cumhur Oner and Wouter J.A. Dhert and Jacqueline Alblas},
  year={2013}
}
A well-known osteogenic agent in the field of regenerative medicine is bone morphogenetic protein-2 (BMP-2). Non-viral delivery of a plasmid containing the gene encoding BMP-2 has shown to induce bone formation in vivo. In order to develop gene activated matrices into larger constructs, we created porosity in a hydrogel using bioprinting technology, thereby allowing better diffusion and blood vessel ingrowth. We were able to produce 3D constructs that were accurate and reproducible in size… CONTINUE READING

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