Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

@article{Vergalli2019PorinsAS,
  title={Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria},
  author={Julia Vergalli and Igor V. Bodrenko and Muriel Masi and Lucile Moyni{\'e} and Silvia Acosta-Guti{\'e}rrez and J. Naismith and Anne Davin-Regli and Matteo Ceccarelli and Bert van den Berg and Mathias Winterhalter and Jean-Marie Pag{\'e}s},
  journal={Nature Reviews Microbiology},
  year={2019},
  volume={18},
  pages={164-176}
}
Gram-negative bacteria and their complex cell envelope, which comprises an outer membrane and an inner membrane, are an important and attractive system for studying the translocation of small molecules across biological membranes. In the outer membrane of Enterobacteriaceae, trimeric porins control the cellular uptake of small molecules, including nutrients and antibacterial agents. The relatively slow porin-mediated passive uptake across the outer membrane and active efflux via efflux pumps in… Expand
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