Pore size distribution in tablets measured with a morphological sieve.

  title={Pore size distribution in tablets measured with a morphological sieve.},
  author={Yu San Wu and Lucas J. van Vliet and Henderik W. Frijlink and Kees van der Voort Maarschalk},
  journal={International journal of pharmaceutics},
  volume={342 1-2},
Porosity and pore structure are important characteristics of tablets, since they influence mechanical strength and many other properties. This paper proposes an alternative method for the characterization of pore structure based on image analysis of SEM micrographs. SEM images were made of sodium chloride tablets made with three different particle sizes. The pore size distribution in these images was determined with a technique referred to as a morphological sieve. The results were compared to… 
Characterization of pore structure in tablets using image analysis
The present research aims to test the hypothesis that the addition of a minor component causes a change in pore shape in the matrix of the primary component, causing a decrease in mechanical
Pore shape in the sodium chloride matrix of tablets after the addition of starch as a second component.
It was concluded that the lower mechanical strength of the tablets made of the binary mixture was caused by the more open pore structure and more larger pores as could be detected with image analysis.
Study of the Porosity of Certain pharmaceutical Tablets using Mercury Intrusion Porosimeter
Porosity and pore structure are important characteristics of pharmaceutical tablets, since they influence the physical properties, such as mechanical strength, density and disintegration time. This
Quantitative Image Analysis for Evaluating the Coating Thickness and Pore Distribution in Coated Small Particles
A characterization method for coating structure based on image analysis, which is particularly promising for the rational design of coated particles in the pharmaceutical industry, can be used as a fast and effective tool to predict coating functionality.
Characterisation of pore structures of pharmaceutical tablets: A review.
The key properties of the pore structures in solid dosage forms are presented and how to measure them are discussed and the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.
Microstructural investigation of tablet compaction and tablet pharmacological properties
In current tablet manufacturing processes, there is a knowledge gap concerning material transformation and the subsequent impact on tablet properties; this gap presents a barrier to rational
Effect of drying methods on the powder
The effect of drying method, a process variable, on the powder and compaction properties of microcrystalline cellulose (MCC) obtained from the partial acid hydrolysis of bleached alpha (α) cellulose
Characterization of alginate-capped nanosilver by fractal and entropy analysis on its transmission electron microphotographs.
The study employs conventional techniques and quantitative image analysis tools to characterize alginate-capped nanosilver synthesized by green methods and was successful in confirming presence and thickness of polymer layer on particles.
Determination of soil grain size distribution by soil sedimentation and image processing
Over the last decades, advances in digital imaging, computational efficiency and digital storage capacity have moved many industries including manufacturing, pharmaceuticals and agriculture to adopt
Functional encapsulation of small particles : quantification and control of the morphology of the coating layers : quantification and control of the morphology of the coating layers
In this chapter, an overview of the important aspects of the formulation and the process development of a functional encapsulated product is given. It is shown that there is a need of quantification


Location-Dependent Analysis of Porosity and Pore Direction in Tablets
The results show an increase in porosity toward the bottom of the compact and showed a preferred orientation of the pores in the direction of compression.
Pore structure and surface area of mannitol powder, granules and tablets determined with mercury porosimetry and nitrogen adsorption.
  • S. Westermarck, A. Juppo, L. Kervinen, J. Yliruusi
  • Materials Science, Medicine
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 1998
Two methods used in pore structure characterisation, mercury porosimetry and nitrogen adsorption, were compared and plastic deformation and fragmentation of powder and granules in compression were observed in volume pore size distributions and surface areas measured.
Compression characteristics of granulated materials. II, Evaluation of granule fragmentation during compression by tablet permeability and porosity measurements
Abstract Lactose was granulated with 5% (w/w) polyvinylpyrrolidone as a binder with a wet massing-screening procedure. Fourteen granulations were produced by using different amounts and types of
Abstract The consolidation and compaction properties of granule fractions prepared by dry granulation (slugging) of α-lactose monohydrate and roller dried β-lactose, respectively, were studied. The
Relationship between breaking force and pore structure of lactose, glucose and mannitol tablets
Abstract The aim of this study was to determine the relationship between the breaking force of lactose, glucose and mannitol tablets and the pore structure characterised by numeric porosity
How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets.
The effect of roll compaction/dry granulation on the ribbon and tablet properties produced using different magnesium carbonates was evaluated and a possible correlation between the particle shape, surface area and the resulting pore structure of tablets produced with the four different types of magnesium carbonate was observed.
Use of tablet tensile strength adjusted for surface area and mean interparticulate distance to evaluate dominating bonding mechanisms.
Adjustment of the tensile strength for both tablet surface area and mean pore radius gave similar bonding strength values for materials bonding mainly by weak distance forces almost independently of compaction pressure, however, particle size and other factors may still affect the compensated strength values.
During compaction of powders the significance of particle fragmentation has been discussed. It seems that the effect of particle properties as well as the effect of additives for the tablet strength
Studies on direct compression of tablets X. Measurement of tablet surface area by permeametry
Abstract A method for measuring the permeability of tablets was developed. The specific surface areas of the tablets were then deduced using the permeability equation corrected for slip flow. The
The effect of granule properties on the pore structure of tablets of sucrose and lactose
Air permeability and liquid penetration of tablets of sucrose and lactose have been measured and it is found that tablets of high permeability gave low final degrees of saturation whereas less permeable tablets became fully saturated.