Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer

@article{Cymes2008PoreopeningMO,
  title={Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer},
  author={Gisela D. Cymes and Claudio Grosman},
  journal={Nature Structural &Molecular Biology},
  year={2008},
  volume={15},
  pages={389-396}
}
The conformational changes underlying cysteine-loop receptor channel gating remain elusive and controversial. We previously developed a single-channel electrophysiological method that allows structural inferences about the transient open-channel conformation to be made from the effect and properties of introduced charges on systematically engineered ionizable amino acids. Here we have applied this methodology to the entire M1 and M3 segments of the muscle nicotinic acetylcholine receptor, two… CONTINUE READING
Highly Cited
This paper has 50 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

fewer than 50 Citations

051015'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 50 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Electrostatic properties of the mechanosensitive channel of small conductance MscS

M. Sotomayor, T. A. van der Straaten, U. Ravaioli, K. Schulten
Biophys. J. 90, • 2006