Pore opening and closing of a pentameric ligand-gated ion channel.

@article{Zhu2010PoreOA,
  title={Pore opening and closing of a pentameric ligand-gated ion channel.},
  author={Fangqiang Zhu and Gerhard Hummer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 46},
  pages={19814-9}
}
Nerve signaling in humans and chemical sensing in bacteria both rely on the controlled opening and closing of the ion-conducting pore in pentameric ligand-gated ion channels. With the help of a multiscale simulation approach that combines mixed elastic network model calculations with molecular dynamics simulations, we study the opening and closing of the pore in Gloeobacter violaceus channel GLIC at atomic resolution. In our simulations of the GLIC transmembrane domain, we first verify that the… CONTINUE READING