Porcine skeletal muscle-derived multipotent PW1pos/Pax7neg interstitial cells: isolation, characterization, and long-term culture.

@article{Lewis2014PorcineSM,
  title={Porcine skeletal muscle-derived multipotent PW1pos/Pax7neg interstitial cells: isolation, characterization, and long-term culture.},
  author={Fiona C. Lewis and Beverley J. Henning and Giovanna Marazzi and David A. Sassoon and Georgina M. Ellison and Bernardo Nadal-Ginard},
  journal={Stem cells translational medicine},
  year={2014},
  volume={3 6},
  pages={702-12}
}
Developing effective strategies for the regeneration of solid tissue requires an understanding of the biology underlying the tissue's endogenous repair mechanisms. PW1/Peg3(pos)/Pax7(neg) skeletal muscle-derived interstitial progenitor cells (PICs) were first identified recently in the interstitium of murine skeletal muscle and shown to contribute to muscle fiber regeneration in vivo. PICs, therefore, represent a novel candidate resident progenitor cell for muscle regeneration. To explore the… CONTINUE READING