Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication.

@article{Sun2012PorcineRA,
  title={Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication.},
  author={Ming-xia Sun and Li Huang and Rui Wang and Ya-Ling Yu and Chen Li and Peng-peng Li and Xiao-chun Hu and Hong-ping Hao and Hassan Zackaria Ali Ishag and Xiang Mao},
  journal={Autophagy},
  year={2012},
  volume={8 10},
  pages={1434-47}
}
An increasing number of studies demonstrate that autophagy, an intrinsic mechanism that can degrade cytoplasmic components, is involved in the infection processes of a variety of pathogens. It can be hijacked by various viruses to facilitate their replication. In this study, we found that PRRSV infection significantly increases the number of double- or single-membrane vesicles in the cytoplasm of host cells in ultrastructural analysis. Our results showed the LC3-I was converted into LC3-II… CONTINUE READING