Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells.

@article{Shi2010PorcineRA,
  title={Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells.},
  author={Xibao Shi and Li Wang and Yubao Zhi and Guangxu Xing and Dong Zhao and Ruiguang Deng and Gaiping Zhang},
  journal={Virus research},
  year={2010},
  volume={153 1},
  pages={151-6}
}
Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically important disease in swine-producing area, and interferon beta (IFN-beta) is the first responder against the animal virus infection. However, whether PRRSV could induce the production of IFN-beta is controversial. In this paper, we first time found that PRRSV could phosphorylate IFN-regulatory factor 3 (IRF-3) and weakly activate the IFN-beta promoter in MARC-145 cells in early infection, but the activations of… CONTINUE READING

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