Porcine nuclear transfer using somatic donor cells altered to express male germ cell function.

@article{Roh2009PorcineNT,
  title={Porcine nuclear transfer using somatic donor cells altered to express male germ cell function.},
  author={Sangho Roh and Hye-yeon Choi and Sang Kyu Park and Cheolhee Won and Bong-Woo Kim and Jung-Hyun Kim and Hoin Kang and Eunsong Lee and Ssang-Goo Cho},
  journal={Reproduction, fertility, and development},
  year={2009},
  volume={21 7},
  pages={
          882-91
        }
}
Recent studies reported that the direct transformation of one differentiated somatic cell type into another is possible. In the present study, we were able to modulate the cell fate of somatic cells to take on male germ cell function by introducing cell extracts derived from porcine testis tissue. Fibroblasts were treated with streptolysin O, which reversibly permeabilises the plasma membrane, and incubated with testis extracts. Our results showed that the testis extracts (TE) could activate… CONTINUE READING
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