Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression.

@article{Xu2013PorcineED,
  title={Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression.},
  author={Xingang Xu and Honglei Zhang and Q. S. Zhang and Yong Huang and Jie Dong and Yabing Liang and Hung-Jen Liu and Dewen Tong},
  journal={Veterinary microbiology},
  year={2013},
  volume={164 3-4},
  pages={
          212-21
        }
}
Porcine epidemic diarrhea (PED) is an acute and highly contagious enteric disease of swine caused by porcine epidemic diarrhea virus (PEDV). The porcine intestinal epithelial cell is the PEDV target cell. In this study, we established a porcine intestinal epithelial cell (IEC) line which can stably express PEDV N protein. We also investigate the subcellular localization and function of PEDV N protein by examining its effects on cell growth, cycle progression, interleukin-8 (IL-8) expression… CONTINUE READING

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