Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.

@article{Yamada2014PorcineCI,
  title={Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model.},
  author={Kazuhiko Yamada and Masayuki Tasaki and Mitsuhiro Sekijima and R. A. Wilkinson and Vincenzo Villani and Shannon G Moran and Taylor A Cormack and Isabel M Hanekamp and Robert J. Hawley and John Scott Arn and Jay A Fishman and Akira Shimizu and David H Sachs},
  journal={Transplantation},
  year={2014},
  volume={98 4},
  pages={411-8}
}
BACKGROUND Recent survivals of our pig-to-baboon kidney xenotransplants have been markedly shorter than the graft survivals we previously reported. The discovery of high levels of porcine cytomegalovirus (pCMV) in one of the rejected xenografts led us to evaluate whether this reduction in graft survival might be because of the inadvertent introduction of pCMV into our α1,3-galactosyltransferase gene knockout swine herd. METHODS Archived frozen sections of xeno-kidney grafts over the past 10… CONTINUE READING
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The pathogenesis and clinical management of cytomegalovirus infection in the organ transplant recipient: the end of the ‘silo hypothesis

  • RH Rubin
  • Curr Opin Infect Dis
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