Porcine Induced Pluripotent Stem Cells Require LIF and Maintain Their Developmental Potential in Early Stage of Embryos

@inproceedings{Cheng2012PorcineIP,
  title={Porcine Induced Pluripotent Stem Cells Require LIF and Maintain Their Developmental Potential in Early Stage of Embryos},
  author={De Cheng and Yanjie Guo and Zhenzhen Li and Yajun Liu and Xing Gao and Yi Gao and Xiang Cheng and Junhe Hu and Huayan Amy Wang},
  booktitle={PloS one},
  year={2012}
}
Porcine induced pluripotent stem (piPS) cell lines have been generated recently by using a cocktail of defined transcription factors, however, the features of authentic piPS cells have not been agreed upon and most of published iPS clones did not meet the stringent requirements of pluripotency. Here, we report the generation of piPS cells from fibroblasts using retrovirus carrying four mouse transcription factors (mOct4, mSox2, mKlf4 and mc-Myc, 4F). Multiple LIF-dependent piPS cell lines were… CONTINUE READING

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