Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms.

Abstract

The risk of Hirschsprung disease (HSCR) is ∼15/100 000 live births per newborn but has been reported to show significant inter-individual variation from the effects of seven common susceptibility alleles at the RET, SEMA3 and NRG1 loci. We show, by analyses of these variants in 997 samples from 376 HSCR families of European ancestry, that significant… (More)
DOI: 10.1093/hmg/ddv051

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@article{Kapoor2015PopulationVI, title={Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms.}, author={Ashish Kapoor and Qian Jiang and Sumantra Chatterjee and Prakash Chakraborty and Maria Ximena Sosa and Courtney Berrios and Aravinda Chakravarti}, journal={Human molecular genetics}, year={2015}, volume={24 10}, pages={2997-3003} }