Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.

@article{Martinez2018PopulationVI,
  title={Population variability in animal health: Influence on dose-exposure-response relationships: Part I: Drug metabolism and transporter systems.},
  author={Marilyn N. Martinez and Michael H Court and Johanna Fink-Gremmels and Katrina L Mealey},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2018},
  volume={41 4},
  pages={
          E57-E67
        }
}
There is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose-exposure-response relationships and can affect the drug residues present in the edible tissues of food-producing animals. To appreciate the pharmacokinetic diversity that may exist across a population of potential drug product… CONTINUE READING
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