Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogs

@article{Woodhams2005PopulationTA,
  title={Population trends associated with skin peptide defenses against chytridiomycosis in Australian frogs},
  author={Douglas C. Woodhams and Louise A. Rollins-Smith and Cynthia Carey and Laura K. Reinert and Michael J. Tyler and Ross A. Alford},
  journal={Oecologia},
  year={2005},
  volume={146},
  pages={531-540}
}
Many species of amphibians in the wet tropics of Australia have experienced population declines linked with the emergence of a skin-invasive chytrid fungus, Batrachochytrium dendrobatidis. An innate defense, antimicrobial peptides produced by granular glands in the skin, may protect some species from disease. Here we present evidence that supports this hypothesis. We tested ten synthesized peptides produced by Australian species, and natural peptide mixtures from five Queensland rainforest… 
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TLDR
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TLDR
It is shown here that the South African clawed frog, Xenopus laevis, is a suitable model for investigating immunity to this pathogen, and data strongly suggest that both innate and adaptive immune defenses are involved in the resistance of X. laev is to lethal B. dendrobatidis infections.
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References

SHOWING 1-10 OF 64 REFERENCES
Antimicrobial peptide defenses against pathogens associated with global amphibian declines.
Endemic Infection of the Amphibian Chytrid Fungus in a Frog Community Post-Decline
TLDR
A longitudinal study of the fungus in individually marked frogs sheds new light on the effect of this threatening infectious process in field, as distinct from laboratory, conditions, and finds a seasonal peak of infection in the cooler months, with no evidence of interannual variation.
Antimicrobial peptide defenses of the Tarahumara frog, Rana tarahumarae.
Ecology of Chytridiomycosis in Rainforest Stream Frog Assemblages of Tropical Queensland
TLDR
The data indicate that at the landscape level, environmental conditions have strong effects on host-pathogen dynamics and interact with species-specific behavior or immune function and may be important underlying determinants of chytridiomycosis epizootics and emergence.
Chytridiomycosis in Native Arizona Frogs
TLDR
Collection of frogs from populations experiencing mortality events at eight sites were found to have characteristic lesions of chytrid fungus infection (Batrachochytrium dendrobatidis), which included diffuse epidermal hyperplasia, hyperkeratosis, and colonization of the keratinized layers of the epidermis by sporangia of the chyTrid.
Experimental Infections of Rana esculenta with Aeromonas hydrophila: A Molecular Mechanism for the Control of the Normal Flora
TLDR
The present experiments are the first combined in vivo and in vitro demonstrations of the function of peptide antibiotics in a vertebrate.
Emerging disease of amphibians cured by elevated body temperature.
TLDR
It is found that thermal environment affects the progress of the disease, and that housing frogs Litoria chloris at an environmental temperature of 37 degrees C for less than 16 h can clear them of the chytrid pathogen Batrachochytrium dendrobatidis.
New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera
TLDR
The secretion of the skin glands of the ‘orange‐thighed frog’ Litoria xanthomera contains seven peptides, one of which is the known hypotensive peptide caerulein, and two new peptides that show antibacterial properties.
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