Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

@article{Mok2015PopulationTO,
  title={Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance},
  author={Sachel Mok and E. Ashley and Pedro E Ferreira and L. Zhu and Zhao-Ting Lin and T. Yeo and K. Chotivanich and M. Imwong and S. Pukrittayakamee and M. Dhorda and C. Nguon and P. Lim and C. Amaratunga and Seila Suon and T. Hien and Y. Htut and M. A. Faiz and M. Onyamboko and M. Mayxay and P. Newton and R. Tripura and C. Woodrow and Olivo Miotto and D. Kwiatkowski and F. Nosten and Nicholas P. J. Day and P. Preiser and N. White and A. Dondorp and R. Fairhurst and Zbynek Bozdech},
  journal={Science},
  year={2015},
  volume={347},
  pages={431 - 435}
}
  • Sachel Mok, E. Ashley, +28 authors Zbynek Bozdech
  • Published 2015
  • Medicine, Biology
  • Science
  • Mechanisms propelling drug resistance If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective by Sibley). Mutations in a region called the K13-propeller are predictive for artemisinin resistance in Southeast Asia. Mok et al. looked at the patterns of gene expression in parasites isolated from more than 1000 patients sampled in Africa, Bangladesh, and the Mekong region. A range of mutations that… CONTINUE READING
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