Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

  title={Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance},
  author={Sachel Mok and Elizabeth A Ashley and Pedro E Ferreira and Lei Zhu and Zhaoting Lin and Tomas Yeo and Kesinee Chotivanich and Mallika Imwong and Sasithon Pukrittayakamee and Mehul Dhorda and Chea Nguon and Pharath Lim and Chanaki Amaratunga and Seila Suon and Tran Tinh Hien and Ye Htut and Mohamed Abul Faiz and Marie A. Onyamboko and Mayfong Mayxay and Paul Newton and Rupam Tripura and Charles J Woodrow and Olivo Miotto and Dominic P Kwiatkowski and François Nosten and Nicholas P J Day and Peter Rainer Preiser and Nicholas J. White and Arjen Mattheus Dondorp and Rick M. Fairhurst and Zbynek Bozdech},
Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are unknown. We analyzed the in vivo transcriptomes of 1043 P. falciparum isolates from patients with acute malaria and found that artemisinin resistance is associated with increased expression of unfolded protein response (UPR) pathways involving the… CONTINUE READING
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