Population toxicokinetics of tetrachloroethylene

  title={Population toxicokinetics of tetrachloroethylene},
  author={Fr{\'e}d{\'e}ric Y. Bois and Andrew Gelman and J. Q. Jiang and Don Maszle and Lauren Zeise and G. Alexeef},
  journal={Archives of Toxicology},
 In assessing the distribution and metabolism of toxic compounds in the body, measurements are not always feasible for ethical or technical reasons. Computer modeling offers a reasonable alternative, but the variability and complexity of biological systems pose unique challenges in model building and adjustment. Recent tools from population pharmacokinetics, Bayesian statistical inference, and physiological modeling can be brought together to solve these problems. As an example, we modeled the… CONTINUE READING


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