Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins.

@article{Hinnebusch1998PopulationSO,
  title={Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins.},
  author={B Joseph Hinnebusch and Alan G Barbour and Blanca I Restrepo and T. Schwan},
  journal={Infection and immunity},
  year={1998},
  volume={66 2},
  pages={432-40}
}
The tick-borne relapsing fever spirochete Borrelia hermsii evades the mammalian immune system by periodically switching expression among members of two multigene families that encode immunogenic, antigenically distinct outer surface proteins. The type strain, B. hermsii HS1, has at least 40 complete genes and pseudogenes that participate in this multiphasic antigenic variation. Originally termed vmp (for variable major protein) genes, they have been reclassified as vsp (for variable small… CONTINUE READING

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