• Corpus ID: 173990507

Population stability risks and biophysical benefits of cell-cell fusion in macrophage, osteoclast, and giant multinucleated cells

  title={Population stability risks and biophysical benefits of cell-cell fusion in macrophage, osteoclast, and giant multinucleated cells},
  author={Jesse L. Silverberg and Pei Ying Ng and Roland Baron and Peng Yin},
  journal={arXiv: Biological Physics},
Plant and animal cells are commonly understood as acquiring specialized functions through differentiation and asymmetric division. However, unique capabilities are also acquired when two or more cells fuse together, mixing cytoplasmic and genetic material. Here, we combine imaging experiments with biophysical modeling to perform the first risk-benefit analysis of cell-cell fusion. On one hand, we find fusion introduces an intrinsic instability to the population dynamics. On the other hand, we… 

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