Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women

@article{Lin2009PopulationspecificFV,
  title={Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women},
  author={Yi-Mei Joy Lin and Huei-chen Ko and Fong-Ming Chang and Tzung Lieh Yeh and Hsiao-Fang Sunny Sun},
  journal={Archives of Women's Mental Health},
  year={2009},
  volume={12},
  pages={401-408}
}
The rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase 2 (TPH2), is one of the most promising candidate genes for psychiatric disorders. Although evidence strongly suggests that the TPH2 is significant in the etiology of major depression and anxiety disorder, whether it also contributes to the etiology of peripartum major depression and anxiety disorder, a specific subtype influenced considerably by other environmental factors like hormones, is unclear. This study… CONTINUE READING