Population-specific expression of antimicrobial peptides conferring pathogen resistance in the invasive ladybird Harmonia axyridis

@article{Gegner2018PopulationspecificEO,
  title={Population-specific expression of antimicrobial peptides conferring pathogen resistance in the invasive ladybird Harmonia axyridis},
  author={T. Gegner and H. Schmidtberg and H. Vogel and A. Vilcinskas},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
The harlequin ladybird Harmonia axyridis has emerged as a model species in the context of invasion biology and possesses an expanded repertoire of antimicrobial peptides (AMPs). Here we measured the expression of 22 AMP genes in adult beetles from native and introduced populations, and from a biocontrol population, allowing us to compare populations differing in terms of invasive performance. Strikingly, we observed population-specific expression profiles for particular AMPs. Following an… Expand
The infection of Harmonia axyridis by a parasitic nematode is mediated by entomopathogenic bacteria and triggers sex-specific host immune responses
TLDR
Evidence is provided that the female immune system responds much more strongly to the nematodes and provokes a more robust invasion strategy involving the bacterial mutualists, which could help develop a biological strategy to counter the spread of this insect pest. Expand
Biological Profiling of Coleoptericins and Coleoptericin-Like Antimicrobial Peptides from the Invasive Harlequin Ladybird Harmonia axyridis.
TLDR
In Insect-derived antimicrobial peptides from the invasive harlequin ladybird Harmonia axyridis, data indicate that colistin potentiates the activity of the AMPs, suggesting they could be developed as adjuvants for topical delivery or administration by inhalation for anti-infective therapy to reduce the necessary dose ofcolistin or to prevent development of colist in resistance in MDR pathogens. Expand
Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni
TLDR
Harmonine is the first animal-derived alkaloid detected to have antischistosomal capacity, and the potential of exploiting insects as a source for the discovery of anthelminthics is highlighted. Expand
Symbiont‐mediated chemical defense in the invasive ladybird Harmonia axyridis
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Test the hypothesis that MPs could be produced by microbial symbionts in H. axyridis as a possible example for outsourcing the synthesis of ecologically important semiochemicals to its gut bacteria and determined that the presence or relative abundance of some of the potential MP producers is also diet-dependent. Expand
Bacterial but not fungal challenge up‐regulates the transcription of Coleoptericin genes in Tenebrio molitor
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The transcriptional response of three AMP genes, Coleoptericin A, B, and C (TmCole A, C and C) in T. molitor in response to bacterial, fungal, and fungal challenges is reported. Expand
RNA interference-mediated silencing of genes involved in the immune responses of the soybean pod borer Leguminivora glycinivorella (Lepidoptera: Olethreutidae)
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Two immune-related SPB genes were identified as potential RNAi targets, which may be used in the development of RNAi-mediated SPB control methods and contribute to the elucidation of the mechanism regulating innate immunity in Lepidoptera species. Expand
Diverse Host Immune Responses of Different Geographical Populations of the Coconut Rhinoceros Beetle to Oryctes Rhinoceros Nudivirus (OrNV) Infection
Oryctes rhinoceros nudivirus (OrNV) is a double-stranded DNA (dsDNA) virus which has been used as a biocontrol agent to suppress coconut rhinoceros beetle (CRB) in the Pacific Islands. Recently a newExpand
Epigenetic Mechanisms Are Involved in Sex-Specific Trans-Generational Immune Priming in the Lepidopteran Model Host Manduca sexta
TLDR
Investigating sex-specific TGIP in insects found that feeding larvae with non-pathogenic Escherichia coli or the entomopathogen Serratia entomophila triggered immune responses in the infected host associated with shifts in both DNA methylation and histone acetylation. Expand
Pathogens associated with invasive or introduced insects threaten the health and diversity of native species.
  • A. Vilcinskas
  • Biology, Medicine
  • Current opinion in insect science
  • 2019
TLDR
Whether the factors driving the loss of insect diversity include invasive and/or introduced insects transmitting pathogens to less-resistant native species and the co-introduction of entomopathogens whose spillover is difficult to control is considered. Expand
Invasion success of a widespread invasive predator may be explained by a high predatory efficacy but may be influenced by pathogen infection
TLDR
It is suggested that the interactions between IAS and pathogens are integral to determining invasion success and impact, and that pathogenic infection resulted in a reduced predatory ability of adult and larval ladybird predators. Expand
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TLDR
It is found that most H. axyridis immunity-related genes were similar in diversity to their counterparts in the reference beetle Tribolium castaneum, but there was an unprecedented expansion among genes encoding antimicrobial peptides and proteins (AMPs) and their induction in response to pathogens. Expand
Comparative transcriptomics in three ladybird species supports a role for immunity in invasion biology
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It is shown that microsporidia carried by the invasive ladybird Harmonia axyridis can kill the native ladybird Adalia bipunctata following the oral uptake of spores, suggesting that their horizontal transmission via intraguild predation may help the invader to outcompete its native competitor. Expand
A switch from constitutive chemical defence to inducible innate immune responses in the invasive ladybird Harmonia axyridis
TLDR
This work demonstrates that H. axyridis beetles differs from other insects by reducing rather than increasing the antimicrobial activity of its haemolymph following the injection of bacteria, and suggests that bacterial challenge induces innate immune responses associated with the synthesis of immunity-related proteins. Expand
Two c-type lysozymes boost the innate immune system of the invasive ladybird Harmonia axyridis.
TLDR
It is suggested that two structurally and functionally distinct lysozymes contribute to innate immune responses of H.axyridis and augment the harmonine and AMP components of the immune response. Expand
Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity
TLDR
Harmonine, which is present in H. axyridis haemolymph, displays broad-spectrum antimicrobial activity that includes human pathogens, and in an Anopheles stephensi mosquito feeding model, harmonine displays transmission-blocking activity. Expand
Behavioral and Immunological Features Promoting the Invasive Performance of the Harlequin Ladybird Harmonia axyridis
TLDR
The behavioral traits and associated semiochemicals that promote the invasive success of H. axyridis are discussed, and the chemical defense compound harmonine and the antimicrobial peptides are thought to confer resistance against the abundant microsporidia carried by H.Axyridis. Expand
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TLDR
It is shown that all H. axyridis beetles sourced from diverse collection sites all over the world carry abundant microsporidia, which suggests that both native and invasive H.Axyridis populations are associated with these tolerated parasites, which were likely to have existed in native populations before expansion rather than being acquired in newly colonized areas. Expand
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The findings suggest that mass rearing of biological control agents may strongly impact genetic diversity and life‐history traits in the Asian harlequin ladybird Harmonia axyridis. Expand
Interactions between the fungal pathogen Beauveria bassiana and three species of coccinellid: Harmonia axyridis, Coccinella septempunctata and Adaliabipunctata
TLDR
This paper compares the susceptibility of three species of coccinellid, H. axyridis (cultures derived from Japan and UK), Coccinella septempunctata and Adalia bipunctata to infection by B. bassiana and discusses the potential for control of H. Expand
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An overview of the invasion history and ecology of H. axyridis globally with consideration of future research perspectives is provided. Expand
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