Population-specific evolution of HIV Gag epitopes in genetically diverged patients.

Abstract

BACKGROUND Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures on HIV can be unique depending on the immunogenetics of host populations. It is therefore logical to hypothesize that the virus… (More)
DOI: 10.1016/j.meegid.2013.02.003

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