Population screening for genetic disorders in the 21st century: evidence, economics, and ethics.

@article{Grosse2010PopulationSF,
  title={Population screening for genetic disorders in the 21st century: evidence, economics, and ethics.},
  author={Scott D Grosse and Wolf Henning Rogowski and Laine Friedman Ross and Martina C Cornel and Wybo Dondorp and Muin J. Khoury},
  journal={Public health genomics},
  year={2010},
  volume={13 2},
  pages={106-15}
}
BACKGROUND Proposals for population screening for genetic diseases require careful scrutiny by decision makers because of the potential for harms and the need to demonstrate benefits commensurate with the opportunity cost of resources expended. METHODS We review current evidence-based processes used in the United States, the United Kingdom, and the Netherlands to assess genetic screening programs, including newborn screening programs, carrier screening, and organized cascade testing of… CONTINUE READING