Population pharmacokinetics of telapristone and its active metabolite CDB-4453

@inproceedings{Morris2011PopulationPO,
  title={Population pharmacokinetics of telapristone and its active metabolite CDB-4453},
  author={Denise Morris},
  year={2011}
}
In this thesis, the population pharmacokinetics of telapristone and its active metabolite, CDB-4453 was evaluated using nonlinear mixed effects modeling (NONMEM). A two-compartment (parent) one compartment (metabolite) mixture model with first order absorption and elimination adequately described the pharmacokinetics of telapristone and CDB-4453. For the Phase I/II pharmacokinetic analysis (effect of renal and hepatic impairment), telapristone was rapidly absorbed with an absorption rate… CONTINUE READING