Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis.

@article{AsnPrieto2014PopulationPO,
  title={Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis.},
  author={Eduardo As{\'i}n-Prieto and Alicia Rodr{\'i}guez-Gasc{\'o}n and I{\~n}aki F. Troc{\'o}niz and Amaia Soraluce and Javier Maynar and Jos{\'e} {\'A}ngel S{\'a}nchez-Izquierdo and Arantxazu Isla},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 1},
  pages={180-9}
}
OBJECTIVES To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill patients undergoing continuous renal replacement therapy (CRRT) and to assess the success of the therapy against susceptible bacteria. PATIENTS AND METHODS Sixteen patients undergoing CRRT with different degrees of renal function were included in the study. Blood and ultrafiltrate samples were drawn after administration of piperacillin/tazobactam (4/0.5 g) every 4, 6 or 8 h. The data were analysed by a… CONTINUE READING
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