Population pharmacokinetics of oseltamivir when coadministered with probenecid.

  title={Population pharmacokinetics of oseltamivir when coadministered with probenecid.},
  author={Craig R. Rayner and Pascal Chanu and R. Gieschke and Lauren M Boak and E. Niclas Jonsson},
  journal={Journal of clinical pharmacology},
  volume={48 8},
Oseltamivir is a potent, selective, oral neuraminidase inhibitor for the treatment and prophylaxis of influenza. Plasma concentrations of the active metabolite, oseltamivir carboxylate, are increased in the presence of probenecid, suggesting that the combination could allow for the use of reduced doses of oseltamivir. To investigate this proposal, we developed a population pharmacokinetic model and simulated the pharmacokinetics of candidate combination regimens of oral oseltamivir (45 mg and… CONTINUE READING

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