Population pharmacokinetics of mycophenolic acid : a comparison between enteric-coated mycophenolate sodium and mycophenolate mofetil in renal transplant recipients.

@article{Winter2008PopulationPO,
  title={Population pharmacokinetics of mycophenolic acid : a comparison between enteric-coated mycophenolate sodium and mycophenolate mofetil in renal transplant recipients.},
  author={Brenda C. M. de Winter and Teun van Gelder and Petra Glander and Dario Cattaneo and H Tedesco-Silva and Irmgard Neumann and Luuk Hilbrands and Reinier M. van Hest and Mark D. Pescovitz and Klemens Budde and Ron A. A. Math{\^o}t},
  journal={Clinical pharmacokinetics},
  year={2008},
  volume={47 12},
  pages={827-38}
}
OBJECTIVE The pharmacokinetics of mycophenolic acid (MPA) were compared in renal transplant patients receiving either mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (EC-MPS). METHODS MPA concentration-time profiles were included from EC-MPS- (n = 208) and MMF-treated (n = 184) patients 4-257 months after renal transplantation. Population pharmacokinetic analysis was performed using nonlinear mixed-effects modelling (NONMEM). A two-compartment model with first-order… CONTINUE READING

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