Population pharmacokinetics of ketorolac in neonates and young infants.

  title={Population pharmacokinetics of ketorolac in neonates and young infants.},
  author={Athena F. Zuppa and John T. Mondick and Lisa Davis and David Jacques Cohen},
  journal={American journal of therapeutics},
  volume={16 2},
Although ketorolac is commonly used as an analgesic in the pediatric population, there is no information on the pharmacokinetics of ketorolac available for children less than 6 months of age. The objective of this analysis was to construct a population pharmacokinetic model to describe ketorolac disposition in young children. Three neonates and 9 infants, median (range) age 0.4-32 weeks, were administered with 0.5 mg/kg of ketorolac. The data were best described by a 2-compartment model, with… CONTINUE READING

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