Population pharmacokinetics of intravenous itraconazole in patients with persistent neutropenic fever.

@article{Lee2009PopulationPO,
  title={Population pharmacokinetics of intravenous itraconazole in patients with persistent neutropenic fever.},
  author={D-G Lee and H Chae and Dong-Seok Yim and Sun Hwa Park and S M Choi and Shin-Hee Kim and J-H Choi and Je-Hyun Yoo and W-S Shin},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2009},
  volume={34 3},
  pages={337-44}
}
PURPOSE Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ therapy at 200 mg/day after loading doses. NONMEM (Version. 5.1.1) was used to estimate population PK parameters. RESULTS Forty-two patients were enrolled in the study. Mean… CONTINUE READING