Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers.

@article{Dowling2008PopulationPO,
  title={Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers.},
  author={Jonathonm Dowling and Geoffrey K Isbister and Carl M. J. Kirkpatrick and Daya Naidoo and Andis Graudins},
  journal={Therapeutic drug monitoring},
  year={2008},
  volume={30 4},
  pages={490-6}
}
To investigate the pharmacokinetics of naloxone in healthy volunteers, we undertook an open-label crossover study in which six male volunteers received naloxone on five occasions: intravenous (0.8 mg), intramuscular (0.8 mg), intranasal (0.8 mg), intravenous (2 mg), and intranasal (2 mg). Samples were collected for 4 hours after administration for 128 samples in total. A population pharmacokinetic analysis was undertaken using NONMEM. The data were best described by a three-compartment model… CONTINUE READING
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