Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein.


AIMS The aims of this observational study were to assess the variability in imatinib pharmacokinetics and to explore the relationship between its disposition and various biological covariates, especially plasma alpha1-acid glycoprotein concentrations. METHODS A population pharmacokinetic analysis was performed using NONMEM based on 321 plasma samples from… (More)