Population pharmacokinetics of fluconazole in liver transplantation: implications for target attainment for infections with Candida albicans and non-albicans spp.

@article{Cojutti2018PopulationPO,
  title={Population pharmacokinetics of fluconazole in liver transplantation: implications for target attainment for infections with Candida albicans and non-albicans spp.},
  author={Pier Giorgio Cojutti and Manuela Lugano and Elda Righi and Giorgio Della Rocca and Matteo Bassetti and William W Hope and Federico Pea},
  journal={European Journal of Clinical Pharmacology},
  year={2018},
  volume={74},
  pages={1449-1459}
}
ObjectivesThe study aims to assess the population pharmacokinetics of fluconazole and the adequacy of current dosages and breakpoints against Candida albicans and non-albicans spp. in liver transplant (LT) patients.Patients and methodsPatients initiated i.v. fluconazole within 1 month from liver transplantation (LTx) for prevention or treatment of Candida spp. infections. Multiple assessments of trough and peak plasma concentrations of fluconazole were undertaken in each patient by means of… CONTINUE READING
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