Population pharmacokinetics of cyclosporine in cardiopulmonary transplant recipients.

  title={Population pharmacokinetics of cyclosporine in cardiopulmonary transplant recipients.},
  author={Sara E Rosenbaum and Gautam Baheti and Andrew K. Trull and Fatemeh Akhlaghi},
  journal={Therapeutic drug monitoring},
  volume={27 2},
A population pharmacokinetic analysis of cyclosporine (CsA) was performed, and the influence of covariates on CsA oral clearance and relative bioavailability was investigated. Data from 48 recipients of heart-lung (n = 21) or single (n = 18) or double (n = 9) lung transplant were included in the study. Patients received oral CsA as either a conventional formulation (Sandimmune) or a microemulsion (Neoral). Steady-state CsA concentrations were measured before and at approximately 2 and 6 hours… CONTINUE READING
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