Population pharmacokinetics of carvedilol in patients with congestive heart failure.

  title={Population pharmacokinetics of carvedilol in patients with congestive heart failure.},
  author={Valentina N. Nikolic and Slobodan M Jankovi{\'c} and Radmila M. Veli{\vc}kovi{\'c}-Radovanovi{\'c} and Svetlana R. Apostolovic and Dragana Stanojevic and Slavoljub Živanovi{\'c} and Nikola Stefanovic and Srdjan Pesic and Tatjana Jevtovi{\'c}-Stoimenov and Janko M Djuric and Veroljub Markovi{\'c} and Jasmina R. Milovanovic},
  journal={Journal of pharmaceutical sciences},
  volume={102 8},
The aim of this study was to derive population pharmacokinetic (PK) model for clearance (CL) of carvedilol in adult patients with chronic heart failure (CHF). Medication and demographic data were obtained from 52 Caucasian patients with CHF taking carvedilol. Population PK analysis was performed by nonlinear mixed-effects modeling (NONMEM) to estimate and identify different factors that could affect carvedilol CL. A total of 55 plasma concentrations were collected from 52 patients with mean age… CONTINUE READING

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