Population pharmacokinetics of carbamazepine in Chinese epilepsy patients.

@article{Jiao2003PopulationPO,
  title={Population pharmacokinetics of carbamazepine in Chinese epilepsy patients.},
  author={Zheng Jiao and Ming-kang Zhong and Xiao-jin Shi and Min Hu and Jing-hua Zhang},
  journal={Therapeutic drug monitoring},
  year={2003},
  volume={25 3},
  pages={279-86}
}
AIM To investigate the pharmacokinetic profile of carbamazepine (CBZ) in Chinese epilepsy patients. MATERIALS AND METHODS Serum samples through concentrations at steady state (n = 687) were collected prospectively from 585 patients during routine clinical care. Data were analyzed by the non-linear mixed-effect modeling (NONMEM) technique with a one-compartment model of first-order absorption and elimination. RESULTS The important determinants of clearance (CL) were total body weight (TBW… CONTINUE READING