Population pharmacokinetics of busulfan in children--letter.

  title={Population pharmacokinetics of busulfan in children--letter.},
  author={Laurent Nguyen and Angelo Paci and Gilles Vassal},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={18 9},
  pages={2715-6; author reply 2717-8}
Appropriate busulfan dosing in children is a highly sensitive issue in the context of high dose-conditioning regimens for bone marrow transplantation (BMT). Indeed, a therapeutic window of plasma exposure to busulfan [area under the curve (AUC) from 900–1,500 mmol/L min] has been defined both avoiding severe toxicities and ensuring efficient engraftment. The article by Trame and colleagues (1) in the November 1, 2011, issue of Clinical Cancer Researchproposed anew individualized i.v. busulfan… CONTINUE READING


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