Population pharmacokinetics of bupivacaine in combined lumbar and sciatic nerve block

OBJECTIVES The primary aim of this study was to establish the population pharmacokinetic (PPK) model of bupivacaine after combined lumbar plexus and sciatic nerve blocks and secondary aim is to assess the effect of patient's characteristics including age, body weight and sex on pharmacokinetic parameters. MATERIALS AND METHODS A total of 31 patients… CONTINUE READING