Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake

  title={Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intake},
  author={Yu-Guan Wen and De-Wei Shang and He-Zhi Xie and Xi-pei Wang and Xiao-jia Ni and Ming Zhang and Wei Lu and Chang Qiu and Xia Liu and Fang-Fang Li and Xuan Li and Fu-Tian Luo},
  journal={Human Psychopharmacology: Clinical and Experimental},
  • Y. Wen, D. Shang, Fu-Tian Luo
  • Published 1 March 2013
  • Medicine, Biology
  • Human Psychopharmacology: Clinical and Experimental
The aim of the study was to better understand blonanserin population pharmacokinetic (PK) characteristics in Chinese healthy subjects. 

Effects of food and grapefruit juice on single-dose pharmacokinetics of blonanserin in healthy Chinese subjects

It is suggested that blonanserin was largely metabolised in the intestinal tract before becoming systemically available, and both food and grapefruit juice enhanced exposure to blonANSerin and N-desethyl blonoserin.

A Simple and Sensitive HPLC-MS/MS Assay for the Quantitation of Blonanserin and N-Desethyl Blonanserin in Rat Plasma and Its Application to Pharmacokinetic Study

The lower limit of quantification (LLOQ), calibration curves, carryover, and matrix effects were sufficiently accurate and precise according to the National Medical Products Administration (NMPA) guidelines for bioanalytical method validation.

Newer antipsychotics and upcoming molecules for schizophrenia

Although regulatory bodies have approved only a handful of antipsychotic drugs in recent years, the wide spectrum of targets that are being explored could eventually bring out antipsychotics with improved efficacy and acceptability, as well as the potential to revolutionize psychiatric practice.

Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay

An advanced virtual screening approach was applied to repurpose 6,218 approved and clinical trial drugs for COVID-19, resulting in 15 and 23 potential repurposed drugs, respectively that can inhibit SARS-CoV-2 replication in Vero cells.

Psychotic mania as the solitary manifestation of neurosyphilis

The present case emphasizes that patients presenting with atypical psychiatric manifestation should be screened for possible syphilis, particularly in the absence of previous psychiatric history, and suggests that combination of blonanserin with antibiotic therapy may be effective in the treatment of the manic and psychotic symptoms secondary to neurosyphilis.

Determination of influence of food intake after a single oral dose of mosapride in beagle dogs using nonlinear mixed effect modeling.

It is suggested that food intake affects both the rate and extent of absorption of mosapride and that the pharmacological effect of mosAPride can differ significantly depending on food intake.



The relationship between the plasma concentration of blonanserin, and its plasma anti‐serotonin 5‐HT2A activity/anti‐dopamine D2 activity ratio and drug‐induced extrapyramidal symptoms

This work investigated the relationships between plasma concentration, the plasma anti‐5‐HT2A activity/anti‐D2 activity (S/D) ratio and extrapyramidal symptoms (EPS) in blonanserin dosing.

Effects of Food on Clinical Pharmacokinetics

No rational scientific basis is found to predict the effect of food for a particular chemical entity or a chemical class of therapeutic agents, and a mechanistic understanding of the effects of food may serve as a key to the pharmacokinetic optimisation of patient therapy, both in outpatients and hospitalised patients of various age groups.

Effect of dose timing in relation to food intake on systemic exposure to blonanserin

Food intake increased the systemic exposure to blonanserin for all time intervals investigated in this study, and the marked effect of food on the bioavailability of blonANSerin should be taken into account in its dosing schedules.

Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.

  • Tadashi OgawaH. Hattori H. Seno
  • Chemistry
    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
  • 2010
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented and seems very useful in forensic and clinical toxicology and pharmacokinetic studies.

Simultaneous determination of blonanserin and its metabolite in human plasma and urine by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.

A new antipsychotic agent:blonanserin

Blonanserin as a new atypical antipsychotic agent is an antagonist of serotonin 5-HT2 and dopamine D2 receptor,and displays low or very low affinities for dopamine D1,adrenergicα1,histamine H1, and

Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration

The current status of information regarding interactions which may influence the gastrointestinal (GI) absorption of orally administered drugs is presented and regional differences in membrane permeability are discussed.

Blonanserin: a review of its use in the management of schizophrenia.

Clinical data suggest that blonanserin is an effective and generally well tolerated option for the short-term treatment of schizophrenia and for those requiring longer-term therapy.

Efficacy and Tolerability of Blonanserin in the Patients With Schizophrenia: A Randomized, Double-blind, Risperidone-Compared Trial

Blonanserin was effective in the treatment of Korean patients with schizophrenia compared with risperidone and was more tolerable with a better safety profile, particularly with respect to prolactin elevation.